CeruLabs
Peer-Reviewed Research

The science ourtechnology stands on.

Cerumenogram technology is built on rigorous peer-reviewed research published in Scientific Reports — one of Nature's leading open-access journals.

27
VOC Biomarkers
Selected by genetic algorithm
100%
Discrimination
In cross-validated studies
2
Published Studies
In Scientific Reports (Nature)
158
Total VOCs Detected
In human cerumen samples
Published Studies

Read the full papers.

The peer-reviewed work that forms the scientific foundation of CeruLabs.

2019Scientific Reports · Nature

Cerumenogram: A New Frontier in Cancer Diagnosis in Humans

Barbosa, J.M.G., Pereira, N.Z., David, L.C. et al.

Abstract

This study introduces the cerumenogram methodology for cancer diagnosis using volatile organic compounds (VOCs) in human cerumen. Using headspace gas chromatography-mass spectrometry (HS/GC-MS), 158 VOCs were identified, with 27 selected by genetic algorithm-partial least squares (GA-PLS) achieving 100% discrimination between cancer patients and healthy controls.

Key Findings

  • 158 volatile organic compounds identified in human cerumen
  • 27 VOCs selected as biomarkers through GA-PLS analysis
  • 100% discrimination accuracy between groups
  • Non-invasive alternative to traditional diagnostic methods
  • 10-fold cross-validation with 10 repetitions
Method:HS/GC-MS at 160°C for 60 min with 3-methylcyclohexanone internal standard
PMID:31409861
DOI:10.1038/s41598-019-48121-4
PubMedFull Text
2025Scientific Reports · Nature

Cerumenogram for Metabolic Diagnosis of Precancer, Cancer, and Remission

Barbosa, J.M.G., et al.

Abstract

This follow-up study extends the cerumenogram methodology to detect precancerous states and monitor remission. The research demonstrates the ability to distinguish between active disease, precancer, and remission states using VOC biomarker patterns.

Key Findings

  • Precancerous metabolic signatures successfully detected
  • Clear distinction between active disease and remission
  • Y-OR vs N-OR probabilistic classification validated
  • Cross-confirmed with PET/CT imaging and histopathology
  • Potential for monitoring treatment response
Method:Enhanced GA-PLS model with expanded cohort validation
PMID:40263376
DOI:10.1038/s41598-025-xxxxx-x
PubMed
Behind the work

Advancing metabolic science.

Cerumenogram research represents a breakthrough in non-invasive metabolic analysis. Led by researchers at Universidade de Franca, this work continues to expand our understanding of volatile organic compound biomarkers and their applications in health screening.

Learn About the ScienceRead Our Blog

Research cited is for educational purposes. CeruLabs is a wellness screening tool and is not FDA-approved. Not intended to diagnose, treat, cure, or prevent any disease. Discuss results with a healthcare provider.